Unverified50% confidenceFactExact time
The matching between guide RNA and the target sequence is not absolutely precise and may cause unintended cutting at sites with similar sequences (off-target effects), thereby triggering insertion-deletion mutations or even cancer risk.
1
Sources
50%
Confidence
Long-term
Relevance
10/23/2026
First Seen
Sources
Related Entities
Related Claims
UnverifiedGene editing tools such as CRISPR may cut other similar sequences elsewhere in the genome when cleaving target gene sites, triggering off-target effects and potential carcinogenic risks.70% similarUnverifiedThe depth of whole-genome sequencing, sample type, and statistical thresholds all affect the sensitivity of off-target detection, so "no off-target detected" does not equal "no off-target."67% similarUnverifiedSilent errors are particularly dangerous in bioinformatics, as functions that swallow exceptions and return empty results can produce biologically plausible but actually incorrect conclusions in genomic analysis pipelines.65% similarUnverified拷贝数变异（CNV）指基因组中通常超过1000个碱基对的较大片段的缺失或重复，与神经发育障碍、癌症等密切相关56% similar
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