Verified75% confidenceFactExact time
Co-folding refers to simultaneously predicting the three-dimensional structures of a protein and a ligand and their binding mode, allowing the protein and ligand to mutually adapt (induced fit effect).
3
Sources
75%
Confidence
Long-term
Relevance
7/6/2026
First Seen
Sources
Related Claims
UnverifiedProtein inverse folding refers to designing amino acid sequences that fold into a given three-dimensional backbone structure; ProteinMPNN and ESM-IF are representative tools.77% similarVerifiedProtein function is jointly determined by the interaction between amino acid sequences and three-dimensional spatial structures.74% similarUnverifiedModifications to amino acid sequences may affect whether a protein can fold correctly and perform functions such as catalysis, binding, or signal transduction.70% similarUnverifiedKnowing the three-dimensional structure of a protein is not the same as understanding how it functions and is regulated within cellular networks, and there is a vast gap between structural prediction and functional understanding.69% similarUnverifiedThe capability for protein sequence–structure joint design is relevant to downstream applications such as drug discovery, antibody engineering, and enzyme design.69% similar
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